MAURICIO POCHETTINO and his Tottenham stars left the city where lightbulbs were first made with their Champions League hopes SCREWED.
Luuk de Jongs 88th minute equaliser for PSV means you can just about pull the plug on the North Londoners chances of the reaching the knockout phase.
And Spurs only had themselves to blame as they fought back from 1-0 down - only to let a 2-1 lead slip.
They must have thought the hosts would not be so dangerous when their highly-rated right-winger Steven Bergwijn was ruled out with an ankle injury.
This forced PSV boss Mark van Bommel to hand 19-year-old Donyell Malen his first Champions League start.
But left-winger Lozano more than made up for his team-mates absence with an outstanding first half display full of pace, cunning and conning.
Hugo Lloris watches the Tottenham game at PSV from the tunnel after red card as Harry Redknapp and Jermaine Jenas make their feelings clearWhen the Mexican was not using his speed and skill to bamboozle the Spurs defence, he was using every trick in the book to try to win a free kick.
This almost led to an early booking for Dembele, who vented his fury after his opponent went to ground far too easily in a touchline tussle between the pair.
Kane, without a goal in the his previous three matches for club and country, twice went close to opening the scoring for Tottenham first with a shot on the turn that was deflected over and then with a header from a Kieran Trippier corner which hit the post.
Lozano then drew another free-kick out of Dembele - who this time was booked much to his disgust as he clearly felt the Mexican bandit had conned the ref again.
Gaston Pereiro, who has scored seven goals in PSVs nine straight League wins this season, nearly rubbed salt into Dembeles wounds by curling the resulting set piece just wide of the target from 25 yards.
Heung-min Son then had a strike from a similar distance saved by keeper Jeroen Zoet at the other end.
But you always felt Tottenhams tactic of playing out from the back - regardless of whether their players were marked - in a bid to pull PSV out of position was going to end with them shooting themselves in the foot.
And so it came to pass on the half-hour mark when, after a several narrow escapes, their last man Alderweireld was mugged by Lozano, who set off towards goal.
Ole Toby mug did well to get back and tackle the PSV ace as he pulled the trigger.
But unfortunately for him and Spurs all he succeeding in doing was deflecting the ball looping over Lloris and into the net.
Tottenham boss Mauricio Pochettino says he wont blame Hugo Lloris after disastrous draw with PSVAlderweireld thought he had made amends five minutes later when his header from another Trippier corner was pushed out by Zoet and Davinson Sanchez smacked home the rebound for what the visitors believed was an equaliser.
But the effort was chalked off as the Slovenian officials, led by referee Slavko Vincic, had spotted a push by Kane in the build up.
Son then brilliantly waltzed his way through the right of PSV defence before seeing Zoet block his shot superbly.
But Tottenham were level in the 40th minute as Trippier got in behind the Dutch defence and pulled the ball back for Moura, whose shot flew into the roof of the net via a deflection or two.
Even then Spurs nearly blew it as they allowed Pereiro to fire off a shot in the box which hit the bar on its way over, much to the visitors relief.
Tottenham looked the only likely winners after the break as Christian Eriksen, playing his first game for a month after recovering from an abdominal injury, had a shot well saved by Zoet.
Their great Dane then turned provider with a succulent cross for Kane to head home the winner in the 54th minute.
The England captain has now scored 11 goals in his first 13 matches in the Champions League.
Sub Erik Lamela went close to adding a third for Tottenham with a shot that hit the bar.
Lloris turbulent season then continued as he was sent off for bringing down Lozano outside of his area in the 79th minute.
Sub keeper Michel Vorm, on for the sacrificed Son, tipped Pereiros resulting free-kick around the post with his first touch.
But there was nothing the Dutch stopper could do to keep out De Jongs close range flick for the leveller two minutes from time.
It means both teams have just one point from their opening three matches - and with Spurs still having to travel to Barcelona it does not look like being enough to take them through.